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Record details
Gene and DNA Sequence
Record information and status
Record ID
115568
Status
Published
Date of creation
2020-05-06 13:42 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-06 13:42 UTC (austein.mcloughlin@cbd.int)
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General information
Name of the gene or DNA sequence
Polymerase acidic protein
Abbreviation
PA
Category of DNA sequence
Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Record #45782
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Characteristics of the protein coding sequence
Biological function
The polymerase acidic protein (PA) complexes with polymerase basic protein 1 and 2 to form an RNA-dependent RNA polymerase. PA is essential for the formation of the RNA polymerase and for viral replication. The complex primes transcription of viral RNA through a mechanism termed cap snatching, where the 5' ends (10 to 15 nucleotides) of host pre-mRNAs are removed. PA is thought to act as the endonuclease that cleaves the host pre-mRNAs. It was also suggested that PA can induce proteolytic degradation of co-expressed proteins.
Additional Information
Other relevant website address or attached documents
UniProtKB - Polymerase acidic protein
The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model.pdf
PA Subunit from Influenza Virus Polymerase Complex Interacts with a Cellular Protein with Homology to a Family of Transcriptional Activators.pdf
Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf
Records referencing this document
(
1
)
ID
Description
1
record(s) found
Modified Organism
1 record
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