Delta-6 elongase is involved in the biosynthesis of polyunsaturated
fatty acids and catalyzes the addition of two carbon-hydrogen
groups to the carboxyl end of γ-linolenic acid, converting it to
dihomo-γ-linolenic acid.
Reactions:
malonyl-CoA + γ-linolenoyl-CoA + H+ → 3-oxodihomo γ-linolenoyl-CoA
+ CO2 + coenzyme A
malonyl-CoA + stearidonoyl-CoA + H+ →
(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + coenzyme A
|