The internal ribosomal entry site (IRES) from encephalomyocarditis
virus (EMCV) is a popular RNA element used widely in experimental
and pharmaceutical applications to express proteins in eukaryotic
cells or cell-free extracts. Inclusion of the wild-type element in
monocistronic or bicistronic messenger RNAs (mRNAs) confers a high
level of cap-independent translation activity to appropriately
configured cistrons.
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