The enzyme imidazoleglycerol-phosphate dehydratase (IGPD) catalyses
the conversion of imidazoleglycerol-phosphate to
imidazoleacetol-phosphate which is a critical step in the histidine
biosynthesis pathway.
It is used in research as a bacterial selection marker, whereby
mutations cause histidine auxotrophy and sensitivity to Cu, Co, and
Ni salts.
|