Modified cecropin peptide coding sequence

CS-CEMA-SYNTH

Modified cecropin peptide

Cecropins are antimicrobial peptides. Cecropins lyse bacterial cell membranes; they also inhibit proline uptake and cause leaky membranes. Cationic antimicrobial peptides which include cecropin also possess antiviral and fungicidal activity.

This modified Cecropin A peptide is a synthetic molecule designed through molecular modelling. It includes the eight N-terminal amino acids of cecropin A from Hyalophora cecropia (Northern Silkworm) caterpillars and the eighteen C-terminal  amino acids of melittin from Apis mellifera (Western Honey Bee), as well as two additional positively-charged amino acid residues at the C-terminus of the molecule.