A c-myc tag is a polypeptide tag derived from the c-myc gene
product and is often used in affinity chromatography for protein
purification or for immunodetection of corresponding fusion
proteins with an anti-myc antibody. The c-myc peptide spans the
eleven amino acid sequence EQKLISEEDL and is a relatively small
protein-tag, therefore.
c-Myc is a protein that functions as a transcription factor
activating the expression of targeted genes upon
hetero-dimerisation with an obligate partner. Direct and indirect
target genes comprise genes that are involved in cell growth, cell
differentiation and apoptosis.
The c-myc oncogene is among the most frequently overexpressed genes
in human cancer
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